Tuesday, April 16, 2019

Three Types of Racing Upgrades Offered by Hypercar Development


Friday, April 5, 2019

How PEA Works to Reduce the Need for Opioids


With an extensive entrepreneurial background, Manny Bojorquez leads companies in areas such as high-end performance vehicles and California legal and medical assistance. Among Manny Bojorquez’s current ventures is peaCURE, which emphasizes a natural supplementation approach through the anti-inflammatory palmitoylethanolamide (PEA).

One of the vital uses of PEA is in helping alleviate the opioid crisis by offering a natural alternative that is safe and effective for managing chronic pain. A major issue for people who use opioids is persistent mast cell activation, which serves to sensitize nociceptors and jumpstart inflammatory processes in the central nervous system.

At the cellular level, this involves sensitization of somatosensory neurons in the spine and microglial cell activation. With opioids highly effective in activating non-neuronal immune cell populations, the end result is that pro-inflammatory and pro-nociceptive processes are promoted, which increases tolerance to the dangerous drugs.

PEA plays a critical role in mediating inflammatory process resolution and helping maintain cellular homeostasis. It down-modulates the activation of microglia and mast cells and reduces the neuropathic pain and inflammation associated with acute stimuli. These analgesic and anti-inflammatory effects target the pathophysiologic mechanisms associated with chronic pain and can thus reduce opioid dependence.